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Pediatric Brain Tumors

Monday, November 19, 2012

Health Beat

Study Offers Clues to Cause of Kids’ Brain Tumors

New research from Washington University School of Medicine is helping scientists better understand common brain tumor.

Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children. In new research, scientists at Washington University School of Medicine in St. Louis have identified a cell growth pathway that is unusually active in pediatric brain tumors known as gliomas. They previously identified the same growth pathway as a critical contributor to brain tumor formation and growth in neurofibromatosis-1 (NF1), an inherited cancer predisposition syndrome. “This suggests that the tools we’ve been developing to diagnose and treat NF1 may also be helpful for sporadic brain tumors,” said senior author David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of …

Tuesday, July 10, 2012

Health Beat

Pediatric Tumors Traced to Stem Cells in Developing Brain

According to study from Washington University School of Medicine.

Stem cells that come from a specific part of the developing brain help fuel the growth of brain tumors caused by an inherited condition, researchers at Washington University School of Medicine in St. Louis report.  Scientists showed in mice that disabling a gene linked to a common pediatric tumor disorder, neurofibromatosis type 1 (NF1), made stem cells from one part of the brain proliferate rapidly. But the same genetic deficit had no effect on stem cells from another brain region. The results can be explained by differences in the way stem cells from these regions of the brain respond to cancer-causing genetic changes.  NF1 is among the world’s most common genetic disorders, occurring in about one of every 3,000 births. It causes a wide …

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